SPRAVATO® Treatment at CooperRiis

Treatment-Resistant Depression (TRD) is a diagnosis for adults with Major Depressive Disorder who have not found adequate relief after trying at least two different antidepressant treatments of adequate dose and duration in their current episode. It affects approximately one out of every three people living with depression.

Because TRD involves a lack of response to traditional medications (which often target serotonin or norepinephrine), treatments like SPRAVATO® are designed to work differently by targeting the glutamate system in the brain.

Spravato® is a nasal spray form of ketamine approved by FDA.

FDA approved to treat adults with treatment-resistant depression (TRD) or major depressive disorder (MDD) with suicidal thoughts or actions.

• Most insurance covers this treatment modality.
• There is patient assistance for un-insured and underinsured individuals.

• Start with 8 induction sessions, 2/week for 4 weeks; then assessment for ongoing use (2x/week or every other week depending on results, decision made in consultation with provider) 
• A comfortable space is provided, dimly lit with recliner, eye covering and most prefer to bring music to listen to during session
• Resident self-administers medication, then is monitored for 2 hours (not allowed to drive for rest of the day)

Yes, it can be used along or in conjunction with oral antidepressants.

Rapid action — effects may begin within hours to days, compared with traditional antidepressants which typically require 4–8 weeks for full effect.

• Support through the process of preauthorization and obtaining medication
• No need to worry about rides after the treatment
• Integration with other services

• Currently we are able to provide this service if the resident transitions into our Asheville Community Program transitional housing
• We can assist with referrals to ensure continuity of care if discharging out of the area
• Soon we will be able to provide to individuals outside of our integrated system of care

These typically occur right after administering and go away same day:

• feeling disconnected from yourself, your thoughts, feelings and things around you
• dizziness
• nausea
• feeling sleepy
• spinning sensation
• decreased feeling of sensitivity (numbness)
• feeling anxious
• lack of energy
• increased blood pressure
• vomiting
• feeling drunk
• headache
• feeling very happy or excited

SPRAVATO® can cause serious side effects, including:

• Sedation, dissociation, and respiratory depression.SPRAVATO® may cause sleepiness (sedation), fainting, dizziness, spinning sensation, anxiety, or feeling disconnected from yourself, your thoughts, feelings, space and time (dissociation), and breathing problems (respiratory depression and respiratory arrest).
  • Tell your healthcare provider right away if you feel like you cannot stay awake or if you feel like you are going to pass out.
  • Your healthcare provider must monitor you for serious side effects for at least 2 hours after taking SPRAVATO®. Your healthcare provider will decide when you are ready to leave the healthcare setting.